Welcome to CAGI project!

The Critical Assessment of Genome Interpretation (CAGI, \'kā-jē\) is a community experiment to objectively assess computational methods for predicting the phenotypic impacts of genomic variation. In this experiment, modeled on the Critical Assessment of Structure Prediction (CASP), participants will be provided genetic variants and will make predictions of resulting molecular, cellular, or organismal phenotype. These predictions will be evaluated against experimental characterizations, and independent assessors will perform the evaluations. Community workshops will be held to disseminate results, assess our collective ability to make accurate and meaningful phenotypic predictions, and better understand progress in the field. From this experiment, we expect to identify bottlenecks in genome interpretation, inform critical areas of future research, and connect researchers from diverse disciplines whose expertise is essential to methods for genome interpretation.

CAGI 2010

We want to express our sincere thanks for everyone who participated in CAGI and RiskSNPs 2010. This initial experiment was a great success with over 100 prediction submissions from 8 countries. The workshop on 10 December 2010 gathered an enthusiastic international group of 40 people at Berkeley. Participants were eager to see CAGI continue, and therefore, we are now organizing CAGI 2011 with Susanna Repo as the organizer, and Steven Brenner and John Moult as the CAGI and riskSNPs chairs.

We are completing prediction assessments from CAGI 2010 for publication. A summary of the proceedings was published in Nature News: Mutation-prediction software rewarded. We want to emphasize that CAGI is a community experiment to understand and improve the interpretation of genome variation. It is not a contest and all predictors were awarded recognition for their participation in the meeting.

The CAGI 2011 prediction season is aimed to begin in June 2011, followed by assessment period starting in September 2011. We may also have “rolling” prediction challenges with different timing. A workshop is planned for the end of the year 2011.

group photo